4SC (VSC)

Business description

4SC is a Munich-based cancer R&D company. Epigenetic compound resminostat (HDAC inhibitor) is the lead candidate for CTCL (Phase II initiated Q416), partnered with Yakult Honsha and Menarini. 4SC is partnered with Link Health for a Phase I oncology asset.

Stock data

Market cap.€51.3m
Last close€2.70
High / Low (52 weeks)€4.1 / €2.1
Stock market listingDE
Forecast net cash (€m)8.4
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual2.316.3(33)
Relative *0.110.3(45.3)

* % Relative to local index

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Company news

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Fri, 06 May 2016 11:37:30 GMT

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Sat, 11 May 2013 18:48:10 GMT

Notable Mergers and Acquisitions 7/16: (MGA) (EBAY) (EPD)/(GEL) (AXE)/(HDS)

Thu, 16 Jul 2015 13:58:54 GMT

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2014A 7.1 (8.3) (8.8) (87.6) N/A N/A
2015A 3.3 (7.9) (8.4) (58.6) N/A N/A
2016E 3.8 (12.8) (12.9) (67.9) N/A N/A
2017E 4.0 (5.9) (6.0) (31.1) N/A N/A

Last updated on 09/02/2017

Investment summary

4SC has initiated its pivotal 150-patient Phase II study with epigenetic compound resminostat (HDAC inhibitor) for cutaneous T-cell lymphoma (CTCL). Top-line data is expected by 2019. Resminostat has also been licensed to Yakult Honsha (Japan) and Menarini (rest of Asia-Pacific). Recently announced positive Phase II results from a more detailed analysis of the HCC Yakult trial data, which could lead to further clinical development. Also, announced appointment of a new CEO and sale of its immunology portfolio streamlining the focus on its core business. Other positives include a partnership with Link Health in China for its oncology Eg5 inhibitor, 4SC-205, promising preclinical data for its epigenetic HDAC/LSD1 inhbitor (4SC-202) and promising preclinical data indicating resminostat could offer therapeutic benefit in combination with cancer immunotherapies. 4SC held €12.3m in cash (gross) at Q316, following a €29m equity issue (7.25m shares at €4.00) in July 2015.

Last updated on 02/03/2017

Industry outlook

Resminostat could become the first HDAC inhibitor to gain EU approval for CTCL (vs four HDACs approved in the US). CTCL has been validated as a target indication for HDACs, with vorinostat (Merck & Co) and romidepsin (Celgene) FDA-approved on Phase II data.

Last updated on 02/03/2017

Key management

Jason Loveridge, CEO
Dr. Anna Niedl , Manager Corporate Communications and Investor
Wolfgang Güssgen, Head of Corporate Communications and IR

Company address

Am Klopferspitz 19a
82152
Planegg-Martinsried
Germany
+49 (0)89 700763-0
View website