4SC (VSC)

Business description

4SC is a Munich-based cancer biopharmaceutical company. Resminostat is the lead candidate for cutaneous T-Cell lymphoma (pivotal study started Q416) and partnered with Yakult Honsha in Japan. It has a second anti-cancer compound, 4SC-202 (planned Phase II H217) and a preclinical asset, 4SC-208. It also partners a Phase I oncology asset.

Stock data

Market cap.€174.5m
Last close€5.69
High / Low (52 weeks)€5.7 / €2.2
Stock market listingDE
Forecast net debt (m)N/A
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual26.554.0155.1
Relative *22.355.7115.3

* % Relative to local index

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Company news

Evonik to Buy Performance Materials from Air Products (APD) in $3.8B Deal

Fri, 06 May 2016 11:37:30 GMT

Investment summary

4SC has recently announced an updated and progressive development plan, which it intends to fund from the recent equity capital raise (€41m gross). It has initiated (late 2016) its pivotal 150-patient study with anti-cancer compound resminostat (HDAC inhibitor) for cutaneous T-cell lymphoma (CTCL). Top-line data is expected by 2019. Resminostat has also been licensed to Yakult Honsha in Japan. 4SC announced in 2016 positive Phase II results from a more detailed analysis of the HCC Yakult trial data, which could lead to further clinical development. Alongside resminostat, 4SC intends to advance 4SC-202 into a first pivotal study (late 2018) and complete formal development of 4SC-208 with the aim of starting Phase I clinical testing (early 2019). Other ongoing positives include a partnership with Link Health in China for its oncology Eg5 inhibitor, 4SC-205 and a worldwide license for 4SC’s preclinical inhibitors of the Kv1.3 ion channel.

Last updated on 06/09/2017

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2015A 3.3 (7.9) (8.4) (58.58) N/A N/A
2016A 2.1 (10.9) (10.9) (54.17) N/A N/A
2017E N/A N/A N/A N/A N/A N/A
2018E N/A N/A N/A N/A N/A N/A

Last updated on 23/08/2017

Latest video

Executive interview - 4SC

Industry outlook

Resminostat could become the first HDAC inhibitor to gain EU approval for CTCL (vs two HDACs approved in the US). CTCL has been validated as a target indication for HDACs, with vorinostat (Merck & Co) and romidepsin (Celgene) FDA-approved on Phase II data.

Last updated on 06/09/2017

Key management

Jason Loveridge, CEO
Dr. Anna Niedl , Manager Corporate Communications and Investor

Company address

Am Klopferspitz 19a
82152
Planegg-Martinsried
Germany
+49 (0)89 700763-0
View website