Celyad (CYAD)

Business description

Celyad is developing an innovative Natural Killer Receptor CAR T-cell therapy (CYAD-01). This targets targets five solid and two hematologic cancers in the THINK study. A colorectal cancer study with chemotherapy (SHRINK) is underway.

Stock data

Market cap.€332.7m
Last close€33.72
High / Low (52 weeks)€54.0 / €17.6
Stock market listingEU
Forecast net cash (€m)36.2
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(13.6)(24.7)87.3
Relative *(13.5)(25)67.6

* % Relative to local index

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Company news

Investment summary

Celyad has seen a near complete response with "clinical validity" in an AML patient treated with CYAD-01 NKR CAR T-cell therapy at the lowest dose in the THINK trial. As two stable disease cases in colorectal cancer have also been seen, Celyad will start to further develop AML and colorectal cancers as initial leads after competing the THINK dose escalation stage. CYAD-01 does not use preconditioning but combination approaches will now be explored. The SHRINK trial is underway in mCRC directly after FOLFOX therapy is approved to start in Belgium. Cash on 30 Sept was €40m due to last into H1 209.

Last updated on 13/12/2017

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2015A 0.0 (27.8) (27.6) (317.0) N/A N/A
2016A 8.5 (24.1) (22.8) (209.0) N/A N/A
2017E 8.3 (26.7) (27.2) (286.0) N/A N/A
2018E 9.0 (24.7) (25.2) (265.0) N/A N/A

Last updated on 08/12/2017

Latest video

Industry outlook

The CYAD-01 near complete response in AML, an intractable cancer, is a major milestone showing that NKR CAR therapy is an alternative to standard CAR-T. Celyad's NKR CAR T-cells target ubiquitous "stress" cancer antigens. Celyad has a leading IP position in allogeneic therapy and a Novartis deal. Two US CAR T-cell therapies are approved and Novartis has filed in the EU so the market will develop over 2018.

Last updated on 13/12/2017

Key management

Michel Lussier, Chairman
Dr Christian Homsy, CEO
Patrick Jeanmart, CFO
Dr Gaëtane Metz, COO

Company address

Rue Edouard Belin 12
1435 Mont-Saint-Guibert
Belgium
+32(0)10 39 41 00
View website