Kazia Therapeutics (KZA)

Business description

Kazia Therapeutics has two clinical stage anti-cancer drugs GDC-0084 (targeting glioblastoma) and Cantrixil (targeting ovarian cancer) and a discovery-stage anti-tropomyosins program. GDC-0084 was inlicensed from Genentech, and Kazia is seeking other in-licence opportunities.

Stock data

Market cap.A$34m
Last closeA$0.71
High / Low (52 weeks)A$ / A$
Stock market listingAU
Forecast net cash (A$m)2.8
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(6.6)82.131.5
Relative *(4)92.431.4

* % Relative to local index

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Company news

Y/E Jun Revenue (A$m) EBITDA (A$m) PBT (A$m) EPS (c) P/E (x) P/CF (x)
2016A 3.7 (10.6) (11.6) (28.44) N/A N/A
2017A 8.6 (10.2) (10.9) (22.81) N/A N/A
2018E 4.0 (11.0) (12.2) (25.25) N/A N/A
2019E 13.6 (4.8) (6.3) (13.07) N/A N/A

Last updated on 08/02/2018

Investment summary

Kazia Therapeutics (formerly Novogen) is developing two groups of anti-cancer compounds, including GDC-0084, a PI3K inhibitor licensed from Genentech that is intended for glioblastoma. The company has commenced a Phase II study of GDC-0084; an initial dose-optimisation study will precede a randomised trial in 228 first-line glioblastoma patients (initial data due Q418, final data 2021). It is also undertaking a Phase I trial of its super-benzopyran drug Cantrixil. The 60-patient Phase I trial in ovarian cancer is expected to report MTD in H118; while the primary aim is to assess safety and tolerability, radiological responses and biomarkers will be assessed for indications of efficacy. Kazia has initiated a next-generation anti-tropomyosin drug discovery program supported by an A$3m government grant. It has outlicensed its preclinical super-benzopyran program to Heaton-Brown Life Sciences, and is collaborating with Noxopharm to support the development of NOX66.

Last updated on 02/03/2018

Industry outlook

Kazia Therapeutics is a biotechnology company listed on the ASX and NASDAQ. Its two main drug technology platforms are super-benzopyrans (SBP) and a PI3K inhibitor. SBP compounds show potent activity against cancer stem cells.

Last updated on 02/03/2018

Key management

Iain Ross, Chairman
James Garner, CEO

Company address

Level 24
300 Barangaroo Avenue
Sydney
NSW 2000
Australia
(+61 2) 9472 4101
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