International Stem Cell (ISCO)

Business description

International Stem Cell is an early-stage biotechnology company developing therapeutic, biomedical and cosmeceutical applications for its proprietary stem form of pluripotent stem cells – human parthenogenetic stem cells (hpSCs). Its lead candidate is a cell therapy treatment for Parkinson’s disease.

Stock data

Market cap.US$4.6m
Last closeUS$1.15
High / Low (52 weeks)US$2.1 / US$0.9
Stock market listingUS
Forecast net debt (US$m)4
Forecast gearing ratio (%)854
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(33.5)(28.1)(46.8)
Relative *(35)(30.8)(54.3)

* % Relative to local index

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Y/E Dec Revenue (US$m) EBITDA (US$m) PBT (US$m) EPS (c) P/E (x) P/CF (x)
2015A 7.6 (5.0) (4.6) (129.29) N/A N/A
2016A 7.2 (5.2) (4.9) (33.82) N/A N/A
2017E 7.6 (4.6) (4.9) (122.16) N/A N/A
2018E 8.3 (7.3) (8.2) (196.08) N/A N/A

Last updated on 24/05/2017

Investment summary

International Stem Cell (ISCO) is an early-stage cell therapy company currently in Phase I/IIa clinical trials to treat Parkinson’s disease (PD), with preliminary data from the recently completed first cohort expected in Q317. The company is also preparing to initiate a Phase II trial in traumatic brain injury in Q317. With its hpSC technology, ISCO has created 15 stem cell lines, each of which is a different HLA type. From this, it creates different cell types such as liver cells, neural cells and three-dimensional eye structures. In addition, ISCO sells skincare and biomedical supplies to the market, generating $7.2m in sales and $1.3m in underlying operating profit in 2016.

Last updated on 01/06/2017

Industry outlook

ISCO’s technology platform is based on human parthenogenetic stem cells (hpSCs). Parthenogenetic stem cells are created from unfertilized human eggs (oocytes) chemically activated to make the cells pluripotent. As hpSCs express fewer parental histocompatibility antigens, they reduce the risk of immune rejection.

Last updated on 01/06/2017

Key management

Donald Wright, Chairman
Andrey Semechkin, Chairman & CEO
Mahnaz Ebrahimi, CFO
Russell Kern, EVP & CSO

Company address

5950 Priestly Drive
Carlsbad
CA 92008
United States
+1 760 940 6383
View website