Mesoblast (MSB)

Business description

Mesoblast is developing adult stem cell therapies based on its proprietary MPC and culture-expanded MSC platforms. It has six late-stage clinical trials across four areas.

Share price chart

Share chart

Stock data

Market cap.A$1086m
Last closeA$3.22
High / Low (52 weeks)A$4.5 / A$3.0
Stock market listingAU
Forecast net cash (A$m)153
Forecast gearing ratio (%)N/A
SectorPharmaceutical & Healthcare

Price performance

Relative *(6.2)(11.2)(22.3)

* % Relative to local index

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Company news

Zacks Lowers Mesoblast limited to Sell (MBLTY)

Tue, 06 Oct 2015 00:45:00 GMT

Mesoblast limited Stock Rating Lowered by Zacks (MBLTY)

Wed, 07 Oct 2015 14:03:45 GMT

Mesoblast limited Downgraded to "Sell" at Zacks (MBLTY)

Tue, 06 Oct 2015 13:18:45 GMT

Mesoblast Limited vs Sirtex Medical Limited: Which should you buy?

Wed, 15 Jul 2015 04:12:01 GMT

Mesoblast limited reports full year results: What you need to know

Mon, 17 Aug 2015 05:08:16 GMT

Y/E Jun Revenue (A$m) EBITDA (A$m) PBT (A$m) EPS (c) P/E (x) P/CF (x)
2013A 24.2 (58.7) (48.8) (17.21) N/A N/A
2014A 27.5 (77.4) (68.8) (21.53) N/A N/A
2015E 37.8 (92.0) (88.8) (26.14) N/A N/A
2016E 19.7 (101.4) (96.3) (28.37) N/A N/A

Last updated on 14/09/2015

Investment summary

Mesoblast's pipeline continues to mature. In early September, JCR-031 was recommended for approval by the Ministry of Health, Labour and Welfare, Japan, for acute graft versus host disease (GVHD); approval is expected shortly. Phase III trials also started in 2014 for MPC-150-IM in congestive heart failure. Interim data are expected in mid 2016 and top-line data in mid 2017. Phase II data in patients with diabetic nephropathy were also recently presented at the ADA in Boston showing a single infusion of Mesoblast's MPCs was safe, reduced damaging inflammation, and preserved or improved renal function over at least 24 weeks. Phase II results in type II diabetes were published in the journal of the American Diabetes Association in late July. A single MPC fusion was shown to be safe and well tolerated in the 60-patient placebo-controlled trial while there was an improvement in glycemic control as shown by a decrease at all timepoints after week one in HbA1c in MPC-treated patients compared with an increase in HbA1c in placebo-controlled patients.

Last updated on 29/09/2015

Industry outlook

Mesoblast is the leading mesenchymal stem cell development company, with two platforms (MPCs, MSCs) and nine clinical candidates in Phase II and III. Alliances with Teva, JCR, Celgene and Lonza underpin the key late-stage programmes.

Last updated on 29/09/2015

Key management

Company address

Level 39
55 Collins Street
Melbourne 3000
+61 3 9639 6036
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