Oryzon Genomics (ORY)

Business description

Oryzon is a Spanish biotechnology company focused on developing novel epigenetic compounds. Lead compound ORY-1001 is partnered with Roche and is undergoing a Phase I/IIa study for acute leukaemia. ORY-2001 has potential for Alzheimer’s disease and has been approved to enter Phase I.

Stock data

Market cap.€62.9m
Last close€1.84
High / Low (52 weeks)€5.1 / €1.8
Stock market listingSP
Forecast net cash (€m)8
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(11.1058)(42.4688)(35.0388)
Relative *(10.5433)(41.0626)(43.9426)

* % Relative to local index

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Company news

Catalan Companies Weigh an Exit as Investors Laud Their Plan B

Wed, 04 Oct 2017 10:52:30 GMT

Oryzon Genomics Receives 1.3M USD Public Aids to Advance Development of its ...

Wed, 30 Dec 2015 12:56:15 GMT

ORYZON to present ORY-2001 preliminary top line Phase I clinical data at the ...

Wed, 25 Jan 2017 09:00:00 GMT

ORYZON Announces First Subject Dosed in Phase I Healthy Volunteer Study ...

Mon, 04 Apr 2016 12:04:43 GMT

ORYZON to present new data on its anti-neurodegenerative drug ORY-2001 at the ...

Mon, 09 Oct 2017 12:11:15 GMT

Investment summary

Oryzon’s expertise lies in developing small molecule inhibitors for epigenetic targets. The lead product ORY-1001 is a first-in-class inhibitor of lysine specific demethylase 1 (LSD1) with positive data from the Phase I/IIa in acute leukemia announced in December 2016. Oryzon's former partner Roche has also initiated a Phase I trial with ORY-1001 in small cell lung cancer. Oryzon is now continuing the development of ORY-1001 in both indications. Oryzon’s second product, ORY-2001, targets Alzheimer’s disease (AD) and reported supportive Phase I data in early April. Preclinical data also support its use in multiple sclerosis and other neurodegenerative indications. ORY-3001 has been recently revealed as the third product to enter pre-clinical development in non-oncological indications. Cash position was €37.5m at end Q217.

Last updated on 03/10/2017

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2015A 7.2 0.7 (0.1) (0.57) N/A 42.3
2016A 5.0 (3.7) (4.7) (17.02) N/A N/A
2017E 4.4 (5.0) (6.4) (20.40) N/A N/A
2018E 7.9 (9.7) (11.0) (32.18) N/A N/A

Last updated on 18/09/2017

Latest video

Executive Interview - Oryzon

Industry outlook

Epigenetics is a relatively young field in terms of drug development. HDACs were among the first epigenetic therapeutics brought to market, and although effective, they have side effects. Oryzon is among the leading clinical stage drug developers with a second generation of epigenetic therapeutics, which have greater selectivity and are expected to show a favourable safety/efficacy profile.

Last updated on 03/10/2017

Key management

Carlos Buesa, CEO

Company address

Sant Ferran 74
Cornellà de Llobregat
Barcelona
08940
United Kingdom
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