Pluristem Therapeutics (PSTI)

Business description

Pluristem is a biotech company, headquartered in Israel, focused on the development of cell-based therapeutics derived from placenta. The company is advancing PLX-PAD for critical limb ischemia (CLI) with a Phase III study on hip fracture. PLX-R18 is being advanced for acute radiation syndrome and hematopoietic cell transplant.

Stock data

Market cap.US$409m
Last closeUS$1.18
High / Low (52 weeks)US$6.5 / US$4.1
Stock market listingUS, Tel Aviv Stock Exchange
Forecast net cash (US$m)28.1
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(7)(15.6)(27.6)
Relative *(7.9)(18.7)(29.2)

* % Relative to local index

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Company news

Can Pluristem Therapeutics Corner The Acute Radiation Syndrome Market?

Tue, 11 Apr 2017 21:45:00 GMT

Pluristem Therapeutics - A Potential Beneficiary Of The 21st Century Cures Act

Fri, 16 Dec 2016 13:18:45 GMT

BRIEF-Innovation Medical Management scraps plan to invest in Israel's ...

Tue, 20 Jun 2017 09:33:45 GMT

Pluristem Therapeutics Inc. Shares See a Change of -3.23% This Week

Sat, 22 Jul 2017 02:26:15 GMT

Pluristem and Sosei CVC to Establish a New Corporation for the ...

Tue, 20 Dec 2016 06:31:03 GMT

Y/E Jun Revenue (US$m) EBITDA (US$m) PBT (US$m) EPS (c) P/E (x) P/CF (x)
2015A 0.4 (27.3) (24.7) (35.11) N/A N/A
2016A 2.8 (25.5) (23.2) (29.22) N/A N/A
2017E 0.0 (31.5) (28.9) (33.10) N/A N/A
2018E 0.0 (41.2) (41.5) (41.79) N/A N/A

Last updated on 20/06/2017

Investment summary

Pluristem reported data from its pilot study of PLX-R18 for the treatment of acute radiation syndrome (ARS). The study included 48 non-human primates (NHP) who were dosed with 4m, 10m, and 20m cells per kg and showed an improvement in survival to 83%, 86% and 67%, respectively, from 50% in the control arm, although the study was not powered to significance. The company will need to perform a pivotal primate study and a human safety study for approval, which we expect in 2019-20.

Last updated on 20/06/2017

Industry outlook

Pluristem has been investigating the potential therapeutic benefit of cells derived from the placenta which offers a rich supply of cells of multiple lineages from tissue that would otherwise be medical waste. Although these cells are not stem cells and lack the immortality and pluripotency to meet that definition, they secrete a wide array of cytokines and growth factors and can exert a potent influence on the function of other cells in the body.

Last updated on 01/06/2017

Key management

Zami Aberman, CEO
Yaky Yanay, CFO
Esther Lukasiewicz Hagai, VP of Clinical & Medical Affairs
Erez Egozi, VP of Finance

Company address

MATAM Advanced Technology Park
Building #5
Haifa
31905
Israel
View website