Sierra Oncology (SRRA)

Business description

Sierra Oncology is developing new therapies targeting the DNA damage response to treat cancer. It is in Phase I/II trials of SRA737, a Chk1 inhibitor, as a monotherapy and in combination with low dose gemcitabine.

Stock data

Market cap.US$191m
Last closeUS$2.57
High / Low (52 weeks)US$3.8 / US$1.1
Stock market listingUS
Forecast net cash (US$m)99.9
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual36.0(14.9)114.2
Relative *32.9(15.9)86.6

* % Relative to local index

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Company news

Y/E Dec Revenue (US$m) EBITDA (US$m) PBT (US$m) EPS (c) P/E (x) P/CF (x)
2016A 0.0 (41.6) (41.4) (136.9) N/A N/A
2017A 0.0 (36.5) (36.0) (72.3) N/A N/A
2018E 0.0 (46.3) (45.9) (65.2) N/A N/A
2019E 0.0 (50.9) (50.5) (68.2) N/A N/A

Last updated on 18/04/2018

Investment summary

Sierra Oncology is a drug developer targeting the DNA damage response (DDR) network to treat cancer. The company has two Phase I/II trials with SRA737 targeting checkpoint kinase 1 (Chk1) in patients with genetic tumor types expected to respond to the drug. Inhibition of Chk1 is lethal in cells with defective p53 (among others), one of the most common cancer mutations, and may also be potentiated by low-dose chemotherapy. SRA737 is in Phase I/II clinical trials, both as a monotherapy and in combination with low dose gemcitabine. There is a planned Phase Ib/II trial of SRA737 in combination with the PARPi niraparib in Q418. Sierra is also in preclinical development with SRA141, a Cdc7 inhibitor with a different DNA damage response mechanism.

Last updated on 27/04/2018

Industry outlook

Chk1 has been a target of interest across the industry with ongoing studies at Eli Lilly and Roche and previous programs by AstraZeneca, Merck, and Pfizer among others.

Last updated on 27/04/2018

Key management

Nick Glover, CEO
Diana Papove, Manager, Corporate Affairs
James Smith, VP Corporate Affairs

Company address

885 West Georgia Street, Suite 2150
Vancouver, British Columbia
V6C 3E8
Canada
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