Sierra Oncology (SRRA)

Business description

Sierra Oncology is developing new therapies targeting the DNA damage response to treat cancer. It is in Phase I clinical trials of SRA737, an inhibitor of Chk1, both as a monotherapy and in combination with chemotherapy. It is also in IND enabling studies of SRA141, a Cdc7 inhibitor with an IND expected in late 2017.

Stock data

Market cap.US$85.7m
Last closeUS$1.64
High / Low (52 weeks)US$1.9 / US$1.1
Stock market listingUS
Forecast net cash (US$m)95
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual5.121.5(7.3)
Relative *2.416.7(23)

* % Relative to local index

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Company news

Jefferies Upgrades Sierra Oncology Inc (SRRA) to Buy

Mon, 23 Oct 2017 10:27:38 GMT

Sierra Oncology to Present at the 2017 BIO Investor Forum

Wed, 11 Oct 2017 10:52:30 GMT

ProNAi Relaunched as Sierra Oncology to Advance DDR-Based Cancer Drugs

Mon, 09 Jan 2017 12:00:00 GMT

Revisiting The ProNAi/Sierra Oncology Thesis 1 Year Later: Still Not Dead In ...

Mon, 17 Jul 2017 17:37:30 GMT

Sierra Oncology encouraged by early progress on SRA737 clinical trials

Mon, 05 Jun 2017 13:26:14 GMT

Y/E Dec Revenue (US$m) EBITDA (US$m) PBT (US$m) EPS (fd) (c) P/E (x) P/CF (x)
2015A 0.0 (32.5) (32.6) (226.2) N/A N/A
2016A 0.0 (41.6) (41.4) (136.9) N/A N/A
2017E 0.0 (38.2) (38.1) (76.0) N/A N/A
2018E 0.0 (43.1) (42.8) (76.6) N/A N/A

Last updated on 02/10/2017

Investment summary

We are initiating coverage on Sierra Oncology, a drug developer targeting the DNA damage response (DDR) network to treat cancer. The company has two Phase I trials with SRA737 targeting checkpoint kinase 1 (Chk1) in patients with genetic tumor types expected to respond to the drug. Inhibition of Chk1 is lethal in cells with defective p53 (among others), one of the most common cancer mutations, and also enhances the response to chemotherapy. Sierra also has the cell division cycle 7 (Cdc7) inhibitor SRA141 in preclinical testing. Our initial valuation is $206m or $3.95/share.

Last updated on 18/09/2017

Key management

Nick Glover, CEO
Diana Papove, Manager, Corporate Affairs
James Smith, VP Corporate Affairs

Company address

885 West Georgia Street, Suite 2150
Vancouver, British Columbia
V6C 3E8
Canada
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