Sierra Oncology (SRRA)

Business description

Sierra Oncology is developing new therapies targeting the DNA damage response to treat cancer. It is in Phase I/II trials of SRA737, an Chk1 inhibitor, as a monotherapy and in combination with low dose gemcitabine.

Stock data

Market cap.US$165.6m
Last closeUS$2.32
High / Low (52 weeks)US$3.8 / US$1.1
Stock market listingUS
Forecast net cash (US$m)95
Forecast gearing ratio (%)N/A
SectorPharmaceutical & healthcare

Price performance

Relative *(22.1)(28)35.2

* % Relative to local index

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Company news

Due Diligence Ramp-Up: Sierra Oncology's DNA Damage Gamble

Thu, 08 Mar 2018 20:26:15 GMT

Sierra Oncology (SRRA) Reports Pre-Clinical Results for Chk1 inhibitor, SRA737 ...

Wed, 14 Mar 2018 21:11:15 GMT

Sareum Holdings: Sierra has 'significantly expanded' clinical development ...

Tue, 27 Feb 2018 15:37:36 GMT

Stocks Stepping Onto Center Stage: Applied Materials, Inc. (AMAT), Sierra ...

Wed, 14 Mar 2018 16:07:30 GMT

Sierra to Report Preclinical Data Demonstrating SRA737 Synergy with PARPi at ...

Wed, 21 Feb 2018 12:11:38 GMT

Y/E Dec Revenue (US$m) EBITDA (US$m) PBT (US$m) EPS (fd) (c) P/E (x) P/CF (x)
2015A 0.0 (32.5) (32.6) (226.2) N/A N/A
2016A 0.0 (41.6) (41.4) (136.9) N/A N/A
2017E 0.0 (38.2) (38.1) (76.0) N/A N/A
2018E 0.0 (43.1) (42.8) (76.6) N/A N/A

Last updated on 28/02/2018

Investment summary

Sierra Oncology is a drug developer targeting the DNA damage response (DDR) network to treat cancer. The company has two Phase I trials with SRA737 targeting checkpoint kinase 1 (Chk1) in patients with genetic tumor types expected to respond to the drug. Inhibition of Chk1 is lethal in cells with defective p53 (among others), one of the most common cancer mutations, and may also be potentiated by low-dose chemotherapy. The company is planning on providing an update on the program in early 2018. Sierra is also preparing for potential clinical studies of SRA737 in combination with other agents (such as immune oncology agents and other DDR inhibitors including PARP inhibitors), and has the cell division cycle 7 (Cdc7) inhibitor SRA141 in preclinical testing.

Last updated on 02/03/2018

Industry outlook

Chk1 has been a target of interest across the industry with previous programs AstraZeneca, Merck, and Pfizer among others and ongoing studies at Eli Lilly and Roche.

Last updated on 02/03/2018

Key management

Nick Glover, CEO
Diana Papove, Manager, Corporate Affairs
James Smith, VP Corporate Affairs

Company address

885 West Georgia Street, Suite 2150
Vancouver, British Columbia
V6C 3E8
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