Transgene (TNG)

Business description

Transgene is a French company developing immunotherapy agents for cancer and infectious diseases. Oncolytic virus Pexa-Vec (Phase III for HCC) and cancer vaccine TG4010 (Phase II for NSCLC) are the lead clinical candidates.

Stock data

Market cap.€192.7m
Last close€3.11
High / Low (52 weeks)€3.6 / €2.5
Stock market listingEU
Forecast net debt (€m)29.4
Forecast gearing ratio (%)164
SectorPharmaceutical & healthcare

Price performance

Relative *(0.7)21.311.1

* % Relative to local index

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Company news

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2015A 9.9 (25.7) (28.9) (78.08) N/A N/A
2016A 10.3 (20.4) (23.1) (42.90) N/A N/A
2017E 8.3 (32.0) (35.0) (62.11) N/A N/A
2018E 8.6 (33.6) (36.8) (65.19) N/A N/A

Last updated on 06/02/2018

Investment summary

Transgene is focused on the development of its cancer immunotherapy products (oncolytic virus Pexa-Vec, MUC1 cancer vaccine TG4010 and TG4001 for HPV) in combination with immune checkpoint inhibitors (ICIs) and infectious disease programmes (TG1050 for HBV). The company is running 10 clinical trials, including a Phase 2 trial testing TG4010+Opdivo in 2L NSCLC, a Phase 2 with Pexa-Vec+Opdivo in 1L advanced liver cancer, a Phase 1b/2 trial of TG4001 in HPV positive cancers in combination with avelumab, a Phase 1 trial with Pexa-Vec+Yervoy in solid tumours, a Phase 1/2 of Pexa-Vec+metronomic cyclophosphamide in HER2 negative breast cancer. Transgene and partner Sillajen are running a global 600-patient Phase 3 study in liver cancer. Transgene has a collaboration with BMS to test TG4010 in combination with Opdivo and chemotherapy in 1L and 2L NSCLC. Gross cash at 30 September 2017 was €40m. Transgene recently raised gross €14.4m by the way of a capital increase, extending financial visibility until mid-2019.

Last updated on 02/03/2018

Industry outlook

Immunotherapies are among the most promising class of products for cancer. Increased attention is now being paid to the use of combination therapy approaches to improve cancer response rates further.

Last updated on 02/03/2018

Key management

Philippe Archinard, Chairman & CEO
Lucie Larguier, Director of IR

Company address

Boulevard Gonthier d’Andernach
Parc d’Innovation - CS80166
+33 (0)3 88 27 91 00
View website