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Celyad (CYAD)

Business description

Celyad is developing an innovative Natural Killer Receptor CAR T-cvell therapy (CYAD-01). This focusses on AML and metastatic coloretal cancer. A comprehensive set of clinical studies is beeing initiated.

Stock data

Market cap.€280.6m
Last close€23.50
High / Low (52 weeks)€53.3 / €20.5
Stock market listingEU
Forecast net cash (€m)45.9
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(2.8)(8.1)(55.3)
Relative *1.2(1.9)(49.1)

* % Relative to local index

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Company news

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2016A 8.5 (21.2) (20.0) (209.0) N/A N/A
2017A 3.5 (22.3) (26.8) (279.0) N/A N/A
2018E 0.0 (26.5) (27.3) (243.0) N/A N/A
2019E 0.0 (27.8) (28.5) (238.0) N/A N/A

Last updated on 17/09/2018

Investment summary

Celyad’s first clinical trial design for its allogeneic NRK CAR T-cell therapy (CYAD-101) is an important milestone and is FDA agreed. The study mirrors the current colorectal SHRINK trial: a combination of autologous CYAD-01 therapy with FOLFOX chemotherapy. This gives Celyad the lead in a mass-market solid cancer, where allogeneic therapy is likely to be essential. Under a revised THINK protocol, a colorectal patient was treated with CAR preconditioning therapy before CYAD-01 dosing. Interim data from THINK are promised in late 2018, probably at ASH. Other studies are running or starting. The May placing gave Celyad a cash boost of €46.1m gross, making €62.4m on 30 June. The H118 operational cash outflow was €13.9m.

Last updated on 28/09/2018

Industry outlook

CAR T-cell therapeutics remains a hot area for investment with increasing interest in the next stage of allogeneic products, where Celyad holds a key patent. Celyad remains in a key position in both AML and mCRC with a strong programme in solid tumours.

Last updated on 28/09/2018

Key management

Michel Lussier, Chairman
Dr Christian Homsy, CEO
Filippo Petti, CFO
Dr Gaëtane Metz, COO

Company address

Rue Edouard Belin 12
1435 Mont-Saint-Guibert
Belgium
+32(0)10 39 41 00
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