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Kazia Therapeutics (KZA)

Business description

Kazia Therapeutics has two clinical stage anti-cancer drugs GDC-0084 (targeting glioblastoma) and Cantrixil (targeting ovarian cancer) and a discovery-stage anti-tropomyosins program. GDC-0084 was inlicensed from Genentech, and Kazia is seeking other in-licence opportunities.

Stock data

Market cap.A$24m
Last closeA$0.49
High / Low (52 weeks)A$ / A$
Stock market listingAU
Forecast net cash (A$m)3.6
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(21)(33.8)11.4
Relative *(23.7)(38.2)1.3

* % Relative to local index

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Company news

Y/E Jun Revenue (A$m) EBITDA (A$m) PBT (A$m) EPS (c) P/E (x) P/CF (x)
2016A 3.7 (10.6) (11.6) (28.44) N/A N/A
2017A 8.6 (10.2) (10.9) (22.81) N/A N/A
2018E 13.2 (2.4) (4.3) (8.71) N/A N/A
2019E 13.6 (5.6) (7.2) (14.42) N/A N/A

Last updated on 14/06/2018

Investment summary

Kazia Therapeutics is developing two groups of anti-cancer compounds, including GDC-0084, a PI3K inhibitor licensed from Genentech that has been granted orphan designation in the US for glioblastoma. It commenced recruitment in a US-based Phase II study of GDC-0084 in March; an initial dose-optimisation lead-in component will precede a randomised trial in 228 first-line glioblastoma patients (final data due 2021). It is also undertaking a Phase I trial of its third generation benzopyran drug Cantrixil. The 60-patient Phase I trial in ovarian cancer is expected to report MTD in Q218; while the primary aim is to assess safety and tolerability, radiological responses and biomarkers will be assessed for indications of efficacy. Kazia has de-emphasised its next-generation anti-tropomyosin drug discovery program which is supported by an A$3m government grant. It has outlicensed its preclinical benzopyran program to Heaton-Brown Life Sciences, and is collaborating with Noxopharm to support the development of NOX66.

Last updated on 29/06/2018

Industry outlook

Kazia Therapeutics is a biotechnology company listed on the ASX and NASDAQ. Its two main drug technology platforms are third generation benzopyrans and a PI3K inhibitor.

Last updated on 29/06/2018

Key management

Iain Ross, Chairman
James Garner, CEO

Company address

Level 24
300 Barangaroo Avenue
Sydney
NSW 2000
Australia
(+61 2) 9472 4101
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