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Onxeo (ONXEO)

Business description

Onxeo is developing innovative oncology drugs based on DNA-targeting and epigenetics. The lead compound, AsiDNA, is a first-in-class DNA break repair inhibitor based on a unique decoy mechanism and currently evaluated in a phase I trial (DRIIV-1) for systemic administration in solid tumors.

Stock data

Market cap.€47.9m
Last close€0.90
High / Low (52 weeks)€1.6 / €0.8
Stock market listingEU
Forecast net cash (€m)6
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceuticals & healthcare

Price performance

%1m3m12m
Actual(4.3)0.0(46.4)
Relative *(9.8)(3.8)(44.7)

* % Relative to local index

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Company news

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (fd) (c) P/E (x) P/CF (x)
2016A 4.4 (21.3) (20.4) (44.64) N/A N/A
2017A 9.5 (17.4) (19.7) (23.58) N/A N/A
2018E 3.4 (7.2) (7.8) (11.83) N/A N/A
2019E 3.5 (11.8) (11.9) (22.56) N/A N/A

Last updated on 17/12/2018

Investment summary

Onxeo’s lead asset AsiDNA, a first-in-class DNA break repair inhibitor, is now being tested in the Phase Ib/II part of the DRIIV-1 trial at the Institut Curie in Paris in patients with advanced solid tumours. AsiDNA has already generated supportive data from a Phase I trial in melanoma using intratumoural injection, but is now being tested via systemic administration. Onxeo is conducting a broad preclinical programme that explores AsiDNA in various settings and combinations with other drugs. AsiDNA is part of the proprietary, novel platON platform, a major R&D expansion announced in October 2017, and is based on decoy oligonucleotides. The platON platform belongs to the so-called DNA damage response (DDR) technology, a domain to which recently marketed PARP inhibitors also belong. After receiving $7.5m from the sale of rights to royalties from Beleodaq and a €5.4m equity financing line, cash reach will extend into Q320 past the AsiDNA Phase I results.

Last updated on 01/02/2019

Industry outlook

The approval of the first PARP inhibitor (olaparib) has kick started the interest of both the scientific community and large pharma in the DNA Damage Response (DDR) field. Few biotechs are already positioned in this emerging field which may be the successor to immuno-oncology.

Last updated on 01/02/2019

Key management

Judith Greciet, CEO
Nicolas Fellmann, CFO
Valérie Leroy, Director, Investor Relations & Corporate Com

Company address

49 Boulevard du Général Martial Valin
Paris
75015
France
+33 (0)1 45 58 71 00
View website