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Oryzon Genomics (ORY)

Business description

Oryzon Genomics is a Spanish biotech focused on epigenetics. ORY-1001 (Phase I/IIa) is being explored for acute leukaemias and SCLC; ORY-2001, its CNS product, is in Phase IIa stage for AD and MS, while newer asset ORY-3001 is being developed for certain orphan indications.

Stock data

Market cap.€139.7m
Last close€4.09
High / Low (52 weeks)€5.0 / €1.8
Stock market listingSP
Forecast net cash (€m)0.1
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual18.769.040.9
Relative *19.171.653.5

* % Relative to local index

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Company news

Investment summary

The next year is shaping up to be transformative for Oryzon with two data readouts from Phase IIa trials with ORY-2001 in Alzheimer’s disease (AD) and multiple sclerosis (MS). In addition, an innovative design basket trial with ORY-2001 in several neuropsychiatric disorders may also deliver first results next year. Oryzon is resuming the development of ORY-1001 in acute myeloid leukaemia (AML) and small-cell lung cancer (SCLC). While Roche’s departure was a setback in 2017, the stars started to align again after the Biogen Abeta antibody data provided a much-needed boost for AD research industry and indirectly for Oryzon’s ORY-2001. Furthermore, a fundamental study published in Cell described the potential of LSD1 inhibition in immunooncology setting adding a new dimension to ORY-1001’s potential. We value Oryzon at €328m or €9.6/share (vs €9.4/share).

Last updated on 18/07/2018

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2016A 5.0 (3.7) (4.7) (17.02) N/A N/A
2017A 4.3 (3.5) (4.6) (14.29) N/A N/A
2018E 7.0 (4.7) (5.6) (16.34) N/A N/A
2019E 6.3 (6.4) (7.3) (21.26) N/A N/A

Last updated on 18/07/2018

Latest video

Executive Interview - Oryzon

Industry outlook

Epigenetics is a relatively young field in terms of drug development. HDACs were among the first epigenetic therapeutics brought to market, and although effective, they have side effects. Oryzon is among the leading clinical stage drug developers with a second generation of epigenetic therapeutics, which have greater selectivity and are expected to show a favourable safety/efficacy profile.

Last updated on 29/06/2018

Key management

Carlos Buesa, CEO

Company address

Sant Ferran 74
Cornellà de Llobregat
Barcelona
08940
United Kingdom
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