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SymBio Pharmaceuticals (4582)

Business description

SymBio is a Japanese specialty pharma company with a focus on oncology and haematology. Treakisym is SymBio's branded formulation of bendamustine HCl. Rigosertib was in-licensed from Onconova.

Stock data

Market cap.¥8365.9m
Last close¥130.00
High / Low (52 weeks)¥267.0 / ¥126.0
Stock market listingTYO
Forecast net cash (¥m)423
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(20.3)(35.3)(48.8)
Relative *(17.5)(35.1)(51.9)

* % Relative to local index

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Company news

Y/E Dec Revenue (¥m) EBITDA (¥m) PBT (¥m) EPS (fd) (¥) P/E (x) P/CF (x)
2016A 2368.0 (2101.0) (2317.0) (59.0) N/A 336.4
2017A 3444.0 (3917.0) (3977.0) (79.8) N/A 529.3
2018E 4203.0 (3004.0) (3030.0) (54.2) N/A 177.0
2019E 4325.0 (3591.0) (3636.0) (62.9) N/A 429.7

Last updated on 21/06/2018

Investment summary

SymBio is a speciality pharma focused on Asia-Pacific markets, and has in-licensed two orphan blood cancer products. Treakisym i.v. was approved for r/r low grade NHL/MCL in 2010 and in 2016 received approvals in CLL and first-line low grade NHL/MCL; these new approvals saw in-market Treakisym sales increase by 32% in Q1 2018, following 61% growth in 2017 (NHI price basis). In August SymBio initiated a Phase III trial in Japan of Treakisym in r/r diffuse large B-cell lymphoma, while in September it in-licensed liquid formulations for injection that will provide Treakisym with patent protection that extends to 2031. A Phase I trial of oral Treakisym commenced in January. Rigosertib i.v. is in development for r/r higher-risk myelodysplastic syndromes (HR-MDS) and is in a pivotal Phase III global study which has expanded from 225 to 360 patients in early 2018; SymBio is enrolling patients in Japan and is aiming for potential filing in 2021. SymBio intends to participate in a planned global trial of high-dose oral rigosertib in untreated HR-MDS.

Last updated on 29/06/2018

Industry outlook

SymBio is focused on in-licensing niche opportunities in hard-to-treat indications often overlooked by big pharma. An in-house screening process to select additional pipeline candidates for development and commercialisation will be key to driving operating leverage.

Last updated on 29/06/2018

Key management

Fuminori Yoshida, Representative Director, President & CEO
Kazuo Asakawa, Corporate Officer
Tsutomu Abe, Corporate Officer

Company address

Toranomon 30 Mori Building
3-2-2
Toranomon
MINATO-KU, Tokyo
105-0001
Japan
+81-3-54721125
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