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Transgene (TNG)

Business description

Transgene is a French company developing immunotherapy agents for cancer and infectious diseases. Oncolytic virus Pexa-Vec (Phase III for HCC) and cancer vaccine TG4010 (Phase II for NSCLC) are the lead clinical candidates.

Stock data

Market cap.€189.3m
Last close€3.04
High / Low (52 weeks)€3.5 / €2.5
Stock market listingEU
Forecast net debt (€m)45.2
Forecast gearing ratio (%)1863
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(3.8)3.1(8.4)
Relative *(2.8)6.6(11.7)

* % Relative to local index

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Company news

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2016A 10.3 (20.4) (23.1) (42.9) N/A N/A
2017A 8.1 (26.4) (35.0) (52.0) N/A N/A
2018E 7.2 (28.4) (36.8) (50.6) N/A N/A
2019E 7.9 (31.1) (34.0) (54.8) N/A N/A

Last updated on 16/07/2018

Investment summary

Transgene is focused on the development of its cancer immunotherapy products in combination with immune checkpoint inhibitors (ICIs) and infectious disease programmes. The company is running 11 clinical trials, including a Phase 2 TG4010 combination trial with Opdivo and chemotherapy in 1L NSCLC, a Phase 2 trial testing TG4010+Opdivo in 2L NSCLC, a Phase 2 with Pexa-Vec+Opdivo in 1L advanced liver cancer, a Phase 1b/2 trial of TG4001 in HPV positive cancers in combination with avelumab, a Phase 1 trial with Pexa-Vec+Yervoy in solid tumours and a Phase 1/2 of Pexa-Vec+metronomic cyclophosphamide in HER2 negative breast cancer. Transgene and partner Sillajen are running a global 600-patient Phase 3 study in liver cancer. Transgene recently announced a strategic agreement with Tasly Biopharmaceuticals for full Greater China rights to T601 and T101 (Transgene received $48m in Tasly shares). Gross cash at 31 March 2017 was €35.6m.

Last updated on 27/07/2018

Industry outlook

Immunotherapies are among the most promising class of products for cancer. Increased attention is now being paid to the use of combination therapy approaches to improve cancer response rates further.

Last updated on 27/07/2018

Key management

Philippe Archinard, Chairman & CEO
Lucie Larguier, Director of IR

Company address

Boulevard Gonthier d’Andernach
Parc d’Innovation - CS80166
Illkirch-Graffensta
F-67405
France
+33 (0)3 88 27 91 00
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