Shield Therapeutics — Next step US Feraccru approval

Shield Therapeutics (AIM: STX)

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Research: Healthcare

Shield Therapeutics — Next step US Feraccru approval

Shield Therapeutics reported FY18 results in line with our expectations. Total revenue of £11.9m included the £11.0m upfront payment from European partner Norgine. Operating expenses were substantially reduced as Shield moved from a direct selling model to out-licensing deals for Feraccru commercialisation. Norgine will roll out Feraccru across additional European countries in 2020, subject to country-by-country reimbursement negotiations. In the US, we expect Feraccru approval in 2019 and that Shield will seek a marketing partner thereafter. The positive AEGIS-H2H data (non-inferiority to IV iron) announced recently should strengthen Feraccru’s appeal. We value Shield at £177m (from £178m).

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Written by

Healthcare

Shield Therapeutics

Next step US Feraccru approval

FY18 results

Pharma & biotech

3 April 2019

Price

76.5p

Market cap

£89m

US$/£0.76, €/£0.85, US$/€0.89

Net cash (£m) at 31 December 2018

9.8

Shares in issue

116.4m

Free float

28%

Code

STX

Primary exchange

AIM

Secondary exchange

N/A

Share price performance

%

1m

3m

12m

Abs

41.0

150.8

363.6

Rel (local)

36.7

128.8

347.4

52-week high/low

76.5p

15.5p

Business description

Shield Therapeutics is a commercial-stage pharmaceutical company. Its proprietary product, Feraccru, is approved by the EMA for iron deficiency and is undergoing review with the US FDA. Feraccru is currently marketed through partners Norgine, AOP Orphan and Ewopharma.

Next events

Feraccru US PDUFA date

27 July 2019

Feraccru launches in additional European countries

2020

Analysts

Dr Susie Jana

+44 (0)20 3077 5700

Dr Daniel Wilkinson

+44 (0)20 3077 5734

Dr Sean Conroy

+44 (0)20 3681 2534

Shield Therapeutics is a research client of Edison Investment Research Limited

Shield Therapeutics reported FY18 results in line with our expectations. Total revenue of £11.9m included the £11.0m upfront payment from European partner Norgine. Operating expenses were substantially reduced as Shield moved from a direct selling model to out-licensing deals for Feraccru commercialisation. Norgine will roll out Feraccru across additional European countries in 2020, subject to country-by-country reimbursement negotiations. In the US, we expect Feraccru approval in 2019 and that Shield will seek a marketing partner thereafter. The positive AEGIS-H2H data (non-inferiority to IV iron) announced recently should strengthen Feraccru’s appeal. We value Shield at £177m (from £178m).

Year end

Revenue (£m)

PBT*
(£m)

EPS*
(p)

DPS
(p)

P/E
(x)

Yield
(%)

12/17

0.64

(18.42)

(15.2)

0.0

N/A

N/A

12/18

11.88

(5.15)

(2.0)

0.0

N/A

N/A

12/19e

2.98

(9.37)

(6.5)

0.0

N/A

N/A

12/20e

2.66

(10.0)

(7.8)

0.0

N/A

N/A

Note: *PBT and EPS are normalised, excluding amortisation of acquired intangibles, exceptional items and share-based payments.

2019 US approval and marketing partner

Key inflections in 2019–20 include potential regulatory approval in the US (and a partnering deal), sales growth across Europe and the US, and potential China out-licensing of Feraccru (discussions with Chinese companies are underway). Partnering strategies enhance economic returns and de-risk the investment case. The AEGIS-H2H marketing study, comparing Feraccru (an oral iron treatment) to the market-leading IV iron (Ferinject), has reported promising top-line data, demonstrating that Feraccru is a non-inferior treatment option for patients with iron deficiency anaemia compared to Ferinject. We believe these data will increase clinical uptake, and positively affect pricing negotiations and reimbursement.

Financials: Cash runway into 2020

Shield reported a net loss of £1.8m in FY18 (FY17: £19.6m), benefiting from the £11m upfront licence payment from Norgine and a significant reduction in operating expenses following the restructuring of the company in 2018. The year-end cash position of £9.8m implies a cash runway into 2020. We forecast a 2019 cash burn of £5.1m and sustainable profitability from 2022. Shield is dependent in the near term on royalty and milestone income from partners. A US partnering deal in 2019 should enable an upfront licensing payment to extend cash runway further.

Valuation: £177m or 152p/share

Our valuation of Shield is at £177.4m or 152p/share (153p/share before). We have rolled forward our model and updated FX rates. As detailed in our initiation note, Fortified for growth, our valuation is based on a risk-adjusted NPV model of Feraccru for IDA in Europe and for CKD/IBD-related IDA in the US market. Our NPV calculation is based on Feraccru achieving 2029 peak sales of €133m in Europe and $251m in the US, utilises a 10% discount rate and risk-adjusts the US opportunity accordingly (75% probability of success).

Exhibit 1: Financial summary

Accounts: IFRS, year-end: December, £000s

 

 

2016

2017

2018

2019e

2020e

PROFIT & LOSS

Revenue

 

 

304.0

637.0

11,881.0

2,980.8

2,663.6

Operating revenues

 

 

304.0

637.0

11,881.0

2,980.8

2,663.6

Cost of sales

 

 

(100.0)

(155.0)

(311.0)

(527.9)

(1,524.5)

Gross profit

 

 

204.0

482.0

11,570.0

2,452.9

1,139.1

Gross margin %

 

 

n/a

n/a

n/a

n/a

0.9

SG&A (expenses)

 

 

(10,675.0)

(16,722.0)

(12,438.0)

(7,324.2)

(6,668.1)

R&D costs

 

 

(2,029.0)

(4,711.0)

(4,300.0)

(4,500.0)

(4,500.0)

Other income/(expense)

 

 

40.0

0.0

0.0

0.0

0.0

EBITDA (reported)

 

 

(10,524.0)

(18,514.0)

(2,814.0)

(7,047.1)

(7,860.9)

Depreciation and amortisation

 

 

(1,936.0)

(2,437.0)

(2,354.0)

(2,324.2)

(2,168.1)

Reported Operating Income

 

 

(12,460.0)

(20,951.0)

(5,168.0)

(9,371.3)

(10,028.9)

Exceptionals and adjustments

 

 

(2,157.0)

(2,571.0)

0.0

0.0

0.0

Adjusted Operating Income

 

 

(10,303.0)

(18,380.0)

(5,168.0)

(9,371.3)

(10,028.9)

Finance income/(expense)

 

 

(3,143.0)

(43.0)

15.0

0.0

(200.0)

Reported PBT

 

 

(15,603.0)

(20,994.0)

(5,153.0)

(9,371.3)

(10,228.9)

Adjusted PBT

 

 

(13,446.0)

(18,423.0)

(5,153.0)

(9,371.3)

(10,228.9)

Income tax expense

 

 

587.0

1,406.0

3,359.0

1,800.0

1,200.0

Reported net income

 

 

(15,016.0)

(19,588.0)

(1,794.0)

(7,571.3)

(9,028.9)

Basic average number of shares, m

 

101.2

112.4

116.4

116.4

116.4

Year-end number of shares, m

 

 

101.2

112.4

116.4

116.4

116.4

Basic EPS (p)

 

 

(14.84)

(17.43)

(2.00)

(6.50)

(7.76)

Adjusted EPS (p)

 

 

(12.71)

(15.15)

(1.54)

(6.50)

(7.76)

Dividend per share (p)

 

 

0.00

0.00

0.00

0.00

0.00

BALANCE SHEET

 

 

 

 

 

 

 

Property, plant and equipment

 

 

19.0

13.0

8.0

5.6

3.9

Goodwill

 

 

0.0

0.0

0.0

0.0

0.0

Intangible assets

 

 

28,984.0

29,961.0

30,957.0

28,885.2

26,968.8

Other non-current assets

 

 

0.0

0.0

0.0

0.0

0.0

Total non-current assets

 

 

29,003.0

29,974.0

30,965.0

28,890.8

26,972.8

Cash and equivalents

 

 

20,978.0

13,299.0

9,776.0

4,706.5

6,444.7

Inventories

 

 

418.0

125.0

109.0

580.1

1,675.3

Trade and other receivables

 

 

1,985.0

1,572.0

1,031.0

1,855.0

5,854.1

Other current assets

 

 

0.0

0.0

1,500.0

1,500.0

1,500.0

Total current assets

 

 

23,381.0

14,996.0

12,416.0

8,641.7

15,474.1

Non-current loans and borrowings

 

 

0.0

0.0

0.0

0.0

8,000.0

Other non-current liabilities

 

 

0.0

0.0

0.0

0.0

0.0

Total non-current liabilities

 

 

0.0

0.0

0.0

0.0

8,000.0

Trade and other payables

 

 

3,827.0

3,501.0

2,548.0

3,770.8

9,214.1

Current loans and borrowings

 

 

0.0

0.0

0.0

0.0

0.0

Other current liabilities

 

 

161.0

262.0

403.0

403.0

403.0

Total current liabilities

 

 

3,988.0

3,763.0

2,951.0

4,173.8

9,617.1

Equity attributable to company

 

 

48,396.0

41,207.0

40,430.0

33,358.7

24,829.8

CASH FLOW STATEMENT

 

 

 

 

 

 

 

Reported net income

 

 

(15,016.0)

(19,588.0)

(1,794.0)

(7,571.3)

(9,028.9)

Depreciation and amortisation

 

 

1,936.0

2,437.0

2,354.0

2,324.2

2,168.1

Share based payments

 

 

288.0

560.0

1,013.0

500.0

500.0

Other adjustments

 

 

3,382.0

39.0

4.0

0.5

0.5

Movements in working capital

 

 

(846.0)

(186.0)

(255.0)

(72.4)

349.0

Interest paid / received

 

 

0.0

0.0

0.0

0.0

0.0

Income taxes paid / received

 

 

0.0

587.0

(1,500.0)

0.0

0.0

Cash from operations (CFO)

 

 

(10,256.0)

(16,151.0)

(178.0)

(4,819.5)

(6,011.8)

Capex

 

 

(3,175.0)

(3,408.0)

(3,345.0)

(250.0)

(250.0)

Acquisitions & disposals net

 

 

0.0

0.0

0.0

0.0

0.0

Other investing activities

 

 

177.0

0.0

0.0

0.0

0.0

Cash used in investing activities (CFIA)

 

 

(2,998.0)

(3,408.0)

(3,345.0)

(250.0)

(250.0)

Net proceeds from issue of shares

 

 

33,507.0

11,880.0

0.0

0.0

0.0

Movements in debt

 

 

0.0

0.0

0.0

0.0

8,000.0

Other financing activities

 

 

0.0

0.0

0.0

0.0

0.0

Cash from financing activities (CFF)

 

 

33,507.0

11,880.0

0.0

0.0

8,000.0

Cash and equivalents at beginning of period

 

 

725.0

20,978.0

13,299.0

9,776.0

4,706.5

Increase/(decrease) in cash and equivalents

 

 

20,253.0

(7,679.0)

(3,523.0)

(5,069.5)

1,738.2

Cash and equivalents at end of period

 

 

20,978.0

13,299.0

9,776.0

4,706.5

6,444.7

Net (debt)/cash

 

 

20,978.0

13,299.0

9,776.0

4,706.5

(1,555.3)

Source: Shield, Edison Investment Research

General disclaimer and copyright

This report has been commissioned by Shield Therapeutics and prepared and issued by Edison, in consideration of a fee payable by Shield Therapeutics. Edison Investment Research standard fees are £49,500 pa for the production and broad dissemination of a detailed note (Outlook) following by regular (typically quarterly) update notes. Fees are paid upfront in cash without recourse. Edison may seek additional fees for the provision of roadshows and related IR services for the client but does not get remunerated for any investment banking services. We never take payment in stock, options or warrants for any of our services.

Accuracy of content: All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report and have not sought for this information to be independently verified. Opinions contained in this report represent those of the Edison analyst at the time of publication. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations.

Exclusion of Liability: To the fullest extent allowed by law, Edison shall not be liable for any direct, indirect or consequential losses, loss of profits, damages, costs or expenses incurred or suffered by you arising out or in connection with the access to, use of or reliance on any information contained on this note.

No personalised advice: The information that we provide should not be construed in any manner whatsoever as, personalised advice. Also, the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The securities described in the report may not be eligible for sale in all jurisdictions or to certain categories of investors.

Investment in securities mentioned: Edison has a restrictive policy relating to personal dealing and conflicts of interest. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report, subject to Edison's policies on personal dealing and conflicts of interest.

Copyright: Copyright 2019 Edison Investment Research Limited (Edison). All rights reserved FTSE International Limited (“FTSE”) © FTSE 2019. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under license. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.

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New Zealand

The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (i.e. without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision.

United Kingdom

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This Communication is being distributed in the United Kingdom and is directed only at (i) persons having professional experience in matters relating to investments, i.e. investment professionals within the meaning of Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended (the "FPO") (ii) high net-worth companies, unincorporated associations or other bodies within the meaning of Article 49 of the FPO and (iii) persons to whom it is otherwise lawful to distribute it. The investment or investment activity to which this document relates is available only to such persons. It is not intended that this document be distributed or passed on, directly or indirectly, to any other class of persons and in any event and under no circumstances should persons of any other description rely on or act upon the contents of this document (nor will such persons be able to purchase shares in the placing).

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The Investment Research is a publication distributed in the United States by Edison Investment Research, Inc. Edison Investment Research, Inc. is registered as an investment adviser with the Securities and Exchange Commission. Edison relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a) (11) of the Investment Advisers Act of 1940 and corresponding state securities laws. This report is a bona fide publication of general and regular circulation offering impersonal investment-related advice, not tailored to a specific investment portfolio or the needs of current and/or prospective subscribers. As such, Edison does not offer or provide personal advice and the research provided is for informational purposes only. No mention of a particular security in this report constitutes a recommendation to buy, sell or hold that or any security, or that any particular security, portfolio of securities, transaction or investment strategy is suitable for any specific person.

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Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

1,185 Avenue of the Americas

3rd Floor, New York, NY 10036

United States of America

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

General disclaimer and copyright

This report has been commissioned by Shield Therapeutics and prepared and issued by Edison, in consideration of a fee payable by Shield Therapeutics. Edison Investment Research standard fees are £49,500 pa for the production and broad dissemination of a detailed note (Outlook) following by regular (typically quarterly) update notes. Fees are paid upfront in cash without recourse. Edison may seek additional fees for the provision of roadshows and related IR services for the client but does not get remunerated for any investment banking services. We never take payment in stock, options or warrants for any of our services.

Accuracy of content: All information used in the publication of this report has been compiled from publicly available sources that are believed to be reliable, however we do not guarantee the accuracy or completeness of this report and have not sought for this information to be independently verified. Opinions contained in this report represent those of the Edison analyst at the time of publication. Forward-looking information or statements in this report contain information that is based on assumptions, forecasts of future results, estimates of amounts not yet determinable, and therefore involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of their subject matter to be materially different from current expectations.

Exclusion of Liability: To the fullest extent allowed by law, Edison shall not be liable for any direct, indirect or consequential losses, loss of profits, damages, costs or expenses incurred or suffered by you arising out or in connection with the access to, use of or reliance on any information contained on this note.

No personalised advice: The information that we provide should not be construed in any manner whatsoever as, personalised advice. Also, the information provided by us should not be construed by any subscriber or prospective subscriber as Edison’s solicitation to effect, or attempt to effect, any transaction in a security. The securities described in the report may not be eligible for sale in all jurisdictions or to certain categories of investors.

Investment in securities mentioned: Edison has a restrictive policy relating to personal dealing and conflicts of interest. Edison Group does not conduct any investment business and, accordingly, does not itself hold any positions in the securities mentioned in this report. However, the respective directors, officers, employees and contractors of Edison may have a position in any or related securities mentioned in this report, subject to Edison's policies on personal dealing and conflicts of interest.

Copyright: Copyright 2019 Edison Investment Research Limited (Edison). All rights reserved FTSE International Limited (“FTSE”) © FTSE 2019. “FTSE®” is a trade mark of the London Stock Exchange Group companies and is used by FTSE International Limited under license. All rights in the FTSE indices and/or FTSE ratings vest in FTSE and/or its licensors. Neither FTSE nor its licensors accept any liability for any errors or omissions in the FTSE indices and/or FTSE ratings or underlying data. No further distribution of FTSE Data is permitted without FTSE’s express written consent.

Australia

Edison Investment Research Pty Ltd (Edison AU) is the Australian subsidiary of Edison. Edison AU is a Corporate Authorised Representative (1252501) of Myonlineadvisers Pty Ltd who holds an Australian Financial Services Licence (Number: 427484). This research is issued in Australia by Edison AU and any access to it, is intended only for "wholesale clients" within the meaning of the Corporations Act 2001 of Australia. Any advice given by Edison AU is general advice only and does not take into account your personal circumstances, needs or objectives. You should, before acting on this advice, consider the appropriateness of the advice, having regard to your objectives, financial situation and needs. If our advice relates to the acquisition, or possible acquisition, of a particular financial product you should read any relevant Product Disclosure Statement or like instrument.

New Zealand

The research in this document is intended for New Zealand resident professional financial advisers or brokers (for use in their roles as financial advisers or brokers) and habitual investors who are “wholesale clients” for the purpose of the Financial Advisers Act 2008 (FAA) (as described in sections 5(c) (1)(a), (b) and (c) of the FAA). This is not a solicitation or inducement to buy, sell, subscribe, or underwrite any securities mentioned or in the topic of this document. For the purpose of the FAA, the content of this report is of a general nature, is intended as a source of general information only and is not intended to constitute a recommendation or opinion in relation to acquiring or disposing (including refraining from acquiring or disposing) of securities. The distribution of this document is not a “personalised service” and, to the extent that it contains any financial advice, is intended only as a “class service” provided by Edison within the meaning of the FAA (i.e. without taking into account the particular financial situation or goals of any person). As such, it should not be relied upon in making an investment decision.

United Kingdom

Neither this document and associated email (together, the "Communication") constitutes or form part of any offer for sale or subscription of, or solicitation of any offer to buy or subscribe for, any securities, nor shall it or any part of it form the basis of, or be relied on in connection with, any contract or commitment whatsoever. Any decision to purchase shares in the Company in the proposed placing should be made solely on the basis of the information to be contained in the admission document to be published in connection therewith.

This Communication is being distributed in the United Kingdom and is directed only at (i) persons having professional experience in matters relating to investments, i.e. investment professionals within the meaning of Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005, as amended (the "FPO") (ii) high net-worth companies, unincorporated associations or other bodies within the meaning of Article 49 of the FPO and (iii) persons to whom it is otherwise lawful to distribute it. The investment or investment activity to which this document relates is available only to such persons. It is not intended that this document be distributed or passed on, directly or indirectly, to any other class of persons and in any event and under no circumstances should persons of any other description rely on or act upon the contents of this document (nor will such persons be able to purchase shares in the placing).

This Communication is being supplied to you solely for your information and may not be reproduced by, further distributed to or published in whole or in part by, any other person.

United States

The Investment Research is a publication distributed in the United States by Edison Investment Research, Inc. Edison Investment Research, Inc. is registered as an investment adviser with the Securities and Exchange Commission. Edison relies upon the "publishers' exclusion" from the definition of investment adviser under Section 202(a) (11) of the Investment Advisers Act of 1940 and corresponding state securities laws. This report is a bona fide publication of general and regular circulation offering impersonal investment-related advice, not tailored to a specific investment portfolio or the needs of current and/or prospective subscribers. As such, Edison does not offer or provide personal advice and the research provided is for informational purposes only. No mention of a particular security in this report constitutes a recommendation to buy, sell or hold that or any security, or that any particular security, portfolio of securities, transaction or investment strategy is suitable for any specific person.

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

1,185 Avenue of the Americas

3rd Floor, New York, NY 10036

United States of America

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

Frankfurt +49 (0)69 78 8076 960

Schumannstrasse 34b

60325 Frankfurt

Germany

London +44 (0)20 3077 5700

280 High Holborn

London, WC1V 7EE

United Kingdom

New York +1 646 653 7026

1,185 Avenue of the Americas

3rd Floor, New York, NY 10036

United States of America

Sydney +61 (0)2 8249 8342

Level 4, Office 1205

95 Pitt Street, Sydney

NSW 2000, Australia

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Atlantis Japan Growth Fund — Plenty of attractive investment opportunities

Atlantis Japan Growth Fund (AJG) is advised by Atlantis Investment Research Corporation (AIRC). Lead adviser Taeko Setaishi says that although consensus Japanese corporate earnings growth is being revised downwards, she is still able to identify primarily smaller-cap companies with promising growth prospects that are trading on attractive valuations. As an example, Setaishi highlights changing dynamics within the Japanese economy, which are generating growth in the widely diverse services sector. AJG’s portfolio is trading on higher valuation multiples than the TOPIX index, but has meaningfully higher forecast earnings growth and a superior return on equity, which have contributed to the fund’s medium- and long-term outperformance versus the benchmark.

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