Impressive initial results from the MITCI Phase Ib trial suggest that Viralytics could push to the forefront of the crowded field of immune checkpoint inhibitor (ICI) combination therapies. The first six melanoma patients treated with Cavatak in combination with Yervoy (ipilimumab) experienced a higher response rate (67%) and lower serious adverse event rate (9%) than other prominent ICI combination therapies. These encouraging initial data bode well for the ongoing Phase Ib trials of Cavatak in combination with Merck’s Keytruda in melanoma, lung and bladder cancer, and are likely to be of great interest to potential partners. We increase our valuation to A$272m (A$192m previously), or A$1.15 per share (was A$1.04).

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