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4SC (VSC)

Business description

4SC is a Munich-based cancer biopharmaceutical company. Resminostat (HDAC inhibitor) is the lead candidate for CTCL (pivotal study started in Q416). It has a second compound, domatinostat (formerly 4SC-202; Phase II) and a preclinical asset, 4SC-208. 4SC has several partners including Yakult Honsha for resminostat in Japan.

Stock data

Market cap.€95.8m
Last close€3.13
High / Low (52 weeks)€8.5 / €3.0
Stock market listingDE
Forecast net cash (€m)22.7
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(2.6)(22.2)(36.7)
Relative *1.1(16)(27.2)

* % Relative to local index

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Company news

Investment summary

4SC’s two lead assets are Resminostat (a broad-spectrum HDAC inhibitor) and Domatinostat (4SC-202; HDAC Class I specific inhibitor). Resminostat is uniquely positioned as a maintenance therapy to make remissions more durable for patients with advanced CTCL, who have achieved remission with systemic therapy. Enrolment is on track to reach 100 patients at the end of 2018 (4SC recruiting in Europe, Partner Yakult recruiting in Japan) and top-line data are expected in late 2019. Yakult has also initiated its own Phase II study for resminostat in biliary tract cancer in combination with S-1 chemotherapy. Domatinostat is being studied in Phase Ib/II SENSITIZE study in combination with pembrolizumab in melanoma. The first patient has recently been enrolled in the second dose cohort and top-line data are expected in H119. A second Phase II study EMERGE in GI cancer is expected to start in H218. 4SC-208 (downstream Hedgehog signalling pathway inhibitor) is the third asset expected to enter clinical development in 2019.

Last updated on 12/11/2018

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2016A 2.1 (10.9) (10.9) (54.17) N/A N/A
2017A 4.2 (9.8) (10.0) (40.58) N/A N/A
2018E 4.7 (17.5) (17.6) (57.39) N/A N/A
2019E 3.1 (19.1) (19.2) (62.58) N/A N/A

Last updated on 12/10/2018

Latest video

Executive interview - 4SC

Industry outlook

Resminostat could become the first HDAC inhibitor to gain EU approval for CTCL (vs two HDACs approved in the US), but more importantly the maintenance treatment indication would be unique, potentially offering a competitive edge in Europe and the US.

Last updated on 12/11/2018

Key management

Jason Loveridge, CEO
Dr. Anna Niedl , Manager Corporate Communications and Investor

Company address

Am Klopferspitz 19a
82152
Planegg-Martinsried
Germany
+49 (0)89 700763-0
View website