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4SC (VSC)

Business description

4SC is a Munich-based cancer biopharmaceutical company. Resminostat (HDAC inhibitor) is the lead candidate for CTCL (pivotal study started in Q416). It has a second compound, domatinostat (formerly 4SC-202; Phase II) and a preclinical asset, 4SC-208. 4SC has several partners including Yakult Honsha for resminostat in Japan.

Stock data

Market cap.€133.8m
Last close€4.37
High / Low (52 weeks)€8.5 / €3.8
Stock market listingDE
Forecast net cash (€m)22.7
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceutical & healthcare

Price performance

%1m3m12m
Actual(8.2)(35.1)2.2
Relative *(8.3)(35.7)0.3

* % Relative to local index

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Company news

Investment summary

4SC’s partner, Yakult Honsha, has recruited the first patient in Japan for the pivotal RESMAIN study. If the trial is successful, Yakult will be able to submit resminostat for approval in Japan. This indicates an external validation of 4SC’s R&D strategy. Resminostat (a broad-spectrum HDAC inhibitor) is uniquely positioned as a maintenance therapy to make remissions more durable for patients with advanced CTCL, who have achieved remission with systemic therapy. Timelines remain unchanged for the study to report data in H119. In addition, Yakult has initiated its own Phase II study for resminostat in biliary tract cancer in combination with S-1 chemotherapy. 4SC has a broad development plan for its second lead product domatinostat (formerly 4SC-202; HDAC Class I specific inhibitor) positioned to be used in combination with checkpoint inhibitors with the rationale to tackle the high non-responder issue. 4SC-208 (downstream Hedgehog signalling pathway inhibitor) is the third asset expected to enter clinical development in 2019.

Last updated on 29/06/2018

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2016A 2.1 (10.9) (10.9) (54.17) N/A N/A
2017A 4.2 (9.8) (10.0) (40.58) N/A N/A
2018E 4.7 (17.5) (17.6) (57.39) N/A N/A
2019E 3.1 (19.1) (19.2) (62.58) N/A N/A

Last updated on 26/06/2018

Latest video

Executive interview - 4SC

Industry outlook

Resminostat could become the first HDAC inhibitor to gain EU approval for CTCL (vs two HDACs approved in the US), but more importantly the maintenance treatment indication would be unique, potentially offering a competitive edge in Europe and the US.

Last updated on 29/06/2018

Key management

Jason Loveridge, CEO
Dr. Anna Niedl , Manager Corporate Communications and Investor

Company address

Am Klopferspitz 19a
82152
Planegg-Martinsried
Germany
+49 (0)89 700763-0
View website