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4SC (VSC)

Business description

4SC is a Munich-based cancer biopharmaceutical company. Resminostat (HDAC inhibitor) is the lead candidate for CTCL (pivotal study started in Q416). It has a second compound, domatinostat (formerly 4SC-202; Phase II). 4SC has several partners including Yakult Honsha for resminostat in Japan.

Stock data

Market cap.€93.6m
Last close€3.06
High / Low (52 weeks)€8.5 / €2.6
Stock market listingDE
Forecast net cash (€m)22.7
Forecast gearing ratio (%)N/A
TeamHealthcare
SectorPharmaceuticals & healthcare

Price performance

%1m3m12m
Actual4.6(11.7)(37.2)
Relative *3.2(5.3)(24.2)

* % Relative to local index

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Company news

4SC AG raises €41m

Sun, 09 Jul 2017 16:41:15 GMT

Wellington Partners backs German biotech company 4SC AG

Wed, 08 Jul 2015 14:53:08 GMT

4SC Signs Licensing and Development Agreement with Menarini for Resminostat in ...

Thu, 16 Apr 2015 11:48:45 GMT

4SC and Yakult Honsha Announce Exclusive License Agreement for Japan for the ...

Thu, 14 Apr 2011 06:56:15 GMT

Global Kinesin Like Protein KI Market Status 2018-2023: 4SC AG , Alnylam ...

Wed, 16 May 2018 07:21:21 GMT

Investment summary

4SC’s two lead assets are Resminostat (a broad-spectrum HDAC inhibitor) and Domatinostat (4SC-202; HDAC Class I specific inhibitor). Resminostat is uniquely positioned as a maintenance therapy to make remissions more durable for patients with advanced CTCL, who have achieved remission with systemic therapy. Enrolment in the RESMAIN study is on track and recently reached 100 patients (4SC recruiting in Europe, Partner Yakult recruiting in Japan) and top-line data are expected in H120. Yakult has also initiated its own Phase II study for resminostat in biliary tract cancer in combination with S-1 chemotherapy. Domatinostat is being studied in Phase Ib/II SENSITIZE study in combination with pembrolizumab in melanoma, top-line data are expected by mid-2019. A second Phase II study EMERGE in GI cancer is expected to start in H218.

Last updated on 02/01/2019

Y/E Dec Revenue (€m) EBITDA (€m) PBT (€m) EPS (c) P/E (x) P/CF (x)
2016A 2.1 (10.9) (10.9) (54.17) N/A N/A
2017A 4.2 (9.8) (10.0) (40.58) N/A N/A
2018E 4.7 (17.5) (17.6) (57.39) N/A N/A
2019E 3.1 (19.1) (19.2) (62.58) N/A N/A

Last updated on 27/11/2018

Latest video

Executive interview - 4SC

Industry outlook

Resminostat could become the first HDAC inhibitor to gain EU approval for CTCL (vs two HDACs approved in the US), but more importantly the maintenance treatment indication would be unique, potentially offering a competitive edge in Europe, the US and Japan.

Last updated on 02/01/2019

Key management

Jason Loveridge, CEO
Dr. Anna Niedl , Manager Corporate Communications and Investor

Company address

Am Klopferspitz 19a
82152
Planegg-Martinsried
Germany
+49 (0)89 700763-0
View website